All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

CD36 maintains the gastric mucosa and associates with gastric disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00549772" target="_blank" >RIV/67985823:_____/21:00549772 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1038/s42003-021-02765-z" target="_blank" >https://doi.org/10.1038/s42003-021-02765-z</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s42003-021-02765-z" target="_blank" >10.1038/s42003-021-02765-z</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    CD36 maintains the gastric mucosa and associates with gastric disease

  • Original language description

    The gastric epithelium is often exposed to injurious elements and failure of appropriate healing predisposes to ulcers, hemorrhage, and ultimately cancer. We examined the gastric function of CD36, a protein linked to disease and homeostasis. We used the tamoxifen model of gastric injury in mice null for Cd36 (Cd36(-/-)), with Cd36 deletion in parietal cells (PC-Cd36(-/-)) or in endothelial cells (EC-Cd36(-/-)). CD36 expresses on corpus ECs, on PC basolateral membranes, and in gastrin and ghrelin cells. Stomachs of Cd36(-/-) mice have altered gland organization and secretion, more fibronectin, and inflammation. Tissue respiration and mitochondrial efficiency are reduced. Phospholipids increased and triglycerides decreased. Mucosal repair after injury is impaired in Cd36(-/-) and EC-Cd36(-/-), not in PC-Cd36(-/-) mice, and is due to defect of progenitor differentiation to PCs, not of progenitor proliferation or mature PC dysfunction. Relevance to humans is explored in the Vanderbilt BioVu using PrediXcan that links genetically-determined gene expression to clinical phenotypes, which associates low CD36 mRNA with gastritis, gastric ulcer, and gastro-intestinal hemorrhage. A CD36 variant predicted to disrupt an enhancer site associates (p < 10(-17)) to death from gastro-intestinal hemorrhage in the UK Biobank. The findings support role of CD36 in gastric tissue repair, and its deletion associated with chronic diseases that can predispose to malignancy.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30105 - Physiology (including cytology)

Result continuities

  • Project

    <a href="/en/project/LTAUSA18104" target="_blank" >LTAUSA18104: The role of antioxidant defense in the synthesis of antidiabetic lipokines</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Communications Biology

  • ISSN

    2399-3642

  • e-ISSN

    2399-3642

  • Volume of the periodical

    4

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    15

  • Pages from-to

    1247

  • UT code for WoS article

    000714075700003

  • EID of the result in the Scopus database

    2-s2.0-85118426796