CD36 maintains the gastric mucosa and associates with gastric disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00549772" target="_blank" >RIV/67985823:_____/21:00549772 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s42003-021-02765-z" target="_blank" >https://doi.org/10.1038/s42003-021-02765-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s42003-021-02765-z" target="_blank" >10.1038/s42003-021-02765-z</a>
Alternative languages
Result language
angličtina
Original language name
CD36 maintains the gastric mucosa and associates with gastric disease
Original language description
The gastric epithelium is often exposed to injurious elements and failure of appropriate healing predisposes to ulcers, hemorrhage, and ultimately cancer. We examined the gastric function of CD36, a protein linked to disease and homeostasis. We used the tamoxifen model of gastric injury in mice null for Cd36 (Cd36(-/-)), with Cd36 deletion in parietal cells (PC-Cd36(-/-)) or in endothelial cells (EC-Cd36(-/-)). CD36 expresses on corpus ECs, on PC basolateral membranes, and in gastrin and ghrelin cells. Stomachs of Cd36(-/-) mice have altered gland organization and secretion, more fibronectin, and inflammation. Tissue respiration and mitochondrial efficiency are reduced. Phospholipids increased and triglycerides decreased. Mucosal repair after injury is impaired in Cd36(-/-) and EC-Cd36(-/-), not in PC-Cd36(-/-) mice, and is due to defect of progenitor differentiation to PCs, not of progenitor proliferation or mature PC dysfunction. Relevance to humans is explored in the Vanderbilt BioVu using PrediXcan that links genetically-determined gene expression to clinical phenotypes, which associates low CD36 mRNA with gastritis, gastric ulcer, and gastro-intestinal hemorrhage. A CD36 variant predicted to disrupt an enhancer site associates (p < 10(-17)) to death from gastro-intestinal hemorrhage in the UK Biobank. The findings support role of CD36 in gastric tissue repair, and its deletion associated with chronic diseases that can predispose to malignancy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/LTAUSA18104" target="_blank" >LTAUSA18104: The role of antioxidant defense in the synthesis of antidiabetic lipokines</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Communications Biology
ISSN
2399-3642
e-ISSN
2399-3642
Volume of the periodical
4
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
1247
UT code for WoS article
000714075700003
EID of the result in the Scopus database
2-s2.0-85118426796