Electro-opening of a microtubule lattice in silico
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00550975" target="_blank" >RIV/67985823:_____/21:00550975 - isvavai.cz</a>
Alternative codes found
RIV/67985882:_____/21:00543296
Result on the web
<a href="https://doi.org/10.1016/j.csbj.2021.02.007" target="_blank" >https://doi.org/10.1016/j.csbj.2021.02.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.csbj.2021.02.007" target="_blank" >10.1016/j.csbj.2021.02.007</a>
Alternative languages
Result language
angličtina
Original language name
Electro-opening of a microtubule lattice in silico
Original language description
Modulation of the structure and function of biomaterials is essential for advancing bio-nanotechnology and biomedicine. Microtubules (MTs) are self-assembled protein polymers that are essential for fundamental cellular processes and key model compounds for the design of active bio-nanomaterials. In this in silico study, a 0.5 μs-long all-atom molecular dynamics simulation of a complete MT with approximately 1.2 million atoms in the system indicated that a nanosecond-scale intense electric field can induce the longitudinal opening of the cylindrical shell of the MT lattice, modifying the structure of the MT. This effect is field-strength- and temperature-dependent and occurs on the cathode side. A model was formulated to explain the opening on the cathode side, which resulted from an electric-field-induced imbalance between electric torque on tubulin dipoles and cohesive forces between tubulin heterodimers. Our results open new avenues for electromagnetic modulation of biological and artificial materials through action on noncovalent molecular interactions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GX20-06873X" target="_blank" >GX20-06873X: SubTHz on-chip devices for controlling protein nanomachines</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Computational and Structural Biotechnology Journal
ISSN
2001-0370
e-ISSN
2001-0370
Volume of the periodical
19
Issue of the periodical within the volume
Mar 4
Country of publishing house
SE - SWEDEN
Number of pages
9
Pages from-to
1488-1496
UT code for WoS article
000684840700020
EID of the result in the Scopus database
2-s2.0-85102655211