Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00551597" target="_blank" >RIV/67985823:_____/21:00551597 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10436585
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/24/13395" target="_blank" >https://www.mdpi.com/1422-0067/22/24/13395</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms222413395" target="_blank" >10.3390/ijms222413395</a>
Alternative languages
Result language
angličtina
Original language name
Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions
Original language description
Apoptosis signal-regulating kinase (ASK) 1, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, modulates diverse responses to oxidative and endoplasmic reticulum (ER) stress and calcium influx. As a crucial cellular stress sensor, ASK1 activates c-Jun N-terminal kinases (JNKs) and p38 MAPKs. Their excessive and sustained activation leads to cell death, inflammation and fibrosis in various tissues and is implicated in the development of many neurological disorders, such as Alzheimer’s, Parkinson’s and Huntington disease and amyotrophic lateral sclerosis, in addition to cardiovascular diseases, diabetes and cancer. However, currently available inhibitors of JNK and p38 kinases either lack efficacy or have undesirable side effects. Therefore, targeted inhibition of their upstream activator, ASK1, stands out as a promising therapeutic strategy for treating such severe pathological conditions. This review summarizes recent structural findings on ASK1 regulation and its role in various diseases, highlighting prospects for ASK1 inhibition in the treatment of these pathologies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
22
Issue of the periodical within the volume
24
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
13395
UT code for WoS article
000738054800001
EID of the result in the Scopus database
2-s2.0-85121853296