Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F22%3A00565699" target="_blank" >RIV/67985823:_____/22:00565699 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/smll.202203515" target="_blank" >https://doi.org/10.1002/smll.202203515</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/smll.202203515" target="_blank" >10.1002/smll.202203515</a>
Alternative languages
Result language
angličtina
Original language name
Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells
Original language description
Cell clusters that collectively migrate from primary tumors appear to be far more potent in forming distant metastases than single cancer cells. A better understanding of the collective cell migration phenomenon and the involvement of various cell types during this process is needed. Here, an in vitro platform based on inverted-pyramidal microwells to follow and quantify the collective migration of hundreds of tumor cell clusters at once is developed. These results indicate that mesenchymal stromal cells (MSCs) or cancer-associated fibroblasts (CAFs) in the heterotypic tumor cell clusters may facilitate metastatic dissemination by transporting low-motile cancer cells in a Rac-dependent manner and that extracellular vesicles secreted by mesenchymal cells only play a minor role in this process. Furthermore, in vivo studies show that cancer cell spheroids containing MSCs or CAFs have faster spreading rates. These findings highlight the active role of co-traveling stromal cells in the collective migration of tumor cell clusters and may help in developing better-targeted therapies.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Small
ISSN
1613-6810
e-ISSN
1613-6829
Volume of the periodical
18
Issue of the periodical within the volume
50
Country of publishing house
DE - GERMANY
Number of pages
16
Pages from-to
2203515
UT code for WoS article
000875469300001
EID of the result in the Scopus database
2-s2.0-85141417473