Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00570367" target="_blank" >RIV/67985823:_____/23:00570367 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.trac.2022.116825" target="_blank" >https://doi.org/10.1016/j.trac.2022.116825</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.trac.2022.116825" target="_blank" >10.1016/j.trac.2022.116825</a>

Result language
angličtina
Original language name
Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research
Original language description
Current metabolomics and lipidomics studies are limited in the number of examined matrices, the breadth and scope of methods, reporting the number of metabolites, and data sharing. Here, we discuss the concept of metabolomics and lipidomics atlases that characterize the quantitative distribution and relationships of metabolites in biological matrices and serve as a resource for future studies. Combined sample extraction is recommended to screen the metabolome and lipidome comprehensively. A multiplatform mass spectrometry-based approach with methods for each fraction should follow to separate and detect metabolites differing in their physicochemical properties. Since many known metabolites are detected through untargeted analysis, routine use of multiple internal standards for quantification is advised. This approach provides semiquantitative data and delivers molar concentrations for selected polar metabolites and lipids. An interactive web tool to query metabolites, generate statistical models, visualize data, and download the results should be developed to access generated data easily.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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