Pre-clinical evidence that methylphenidate increases motivation and/or reward preference to search for high value rewards

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00570433" target="_blank" >RIV/67985823:_____/23:00570433 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.bbr.2022.114065" target="_blank" >https://doi.org/10.1016/j.bbr.2022.114065</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbr.2022.114065" target="_blank" >10.1016/j.bbr.2022.114065</a>

Result language

angličtina

Original language name

Pre-clinical evidence that methylphenidate increases motivation and/or reward preference to search for high value rewards

Original language description

Methylphenidate is a stimulant used to treat attention deficit and hyperactivity disorder (ADHD). In the last decade, illicit use of methylphenidate has increased among healthy young adults, who consume the drug under the assumption that it will improve cognitive performance. However, the studies that aimed to assess the methylphenidate effects on memory are not consistent. Here, we tested whether the effect of methylphenidate on a spatial memory task can be explained as a motivational and/or a reward effect. We tested the effects of acute and chronic i.p. administration of 0.3, 1 or 3 mg/kg of methylphenidate on motivation, learning and memory by using the 8-arm radial maze task. Adult male Wistar rats learned that 3 of the 8 arms of the maze were consistently baited with 1, 3, or 6 sucrose pellets, and the number of entries and reentries into reinforced and non-reinforced arms of the maze were scored. Neither acute nor chronic (20 days) methylphenidate treatment affected the number of entries in the non-baited arms. However, chronic, but not acute, 1–3 mg/kg methylphenidate increased the number of reentries in the higher reward arms, which suggests a motivational/rewarding effect rather than a working memory deficit. In agreement with this hypothesis, the methylphenidate treatment also decreased the approach latency to the higher reward arms, increased the approach latency to the low reward arm, and increased the time spent in the high, but not low, reward arm. These findings suggest that methylphenidate may act more as a motivational enhancer rather than a cognitive enhancer in healthy people.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NU20-04-00147" target="_blank" >NU20-04-00147: Obsessive-compulsive disorder as a decision-making disease: translational probe of aberrant error signalling and coordination of brain networks targeting causal interactions and clues for therapy.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Behavioural Brain Research

ISSN

0166-4328

e-ISSN

1872-7549

Volume of the periodical

437

Issue of the periodical within the volume

2 February

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

114065

UT code for WoS article

000862723900007

EID of the result in the Scopus database

2-s2.0-85138020181