CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00571373" target="_blank" >RIV/67985823:_____/23:00571373 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/23:00083949 RIV/00216208:11310/23:10465899 RIV/00216208:11110/23:10465899
Result on the web
<a href="https://doi.org/10.1371/journal.pone.0283276" target="_blank" >https://doi.org/10.1371/journal.pone.0283276</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0283276" target="_blank" >10.1371/journal.pone.0283276</a>
Alternative languages
Result language
angličtina
Original language name
CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study
Original language description
Thermogenesis in brown adipose tissue (BAT) uses intracellular triglycerides, circulating free fatty acids and glucose as the main substrates. The objective of the current study was to analyse the role of CD36 fatty acid translocase in regulation of glucose and fatty acid utilisation in BAT. BAT isolated from spontaneously hypertensive rat (SHR) with mutant Cd36 gene and SHR-Cd36 transgenic rats with wild type variant was incubated in media containing labeled glucose and palmitate to measure substrate incorporation and oxidation. SHR-Cd36 versus SHR rats showed significantly increased glucose incorporation into intracellular lipids associated with reduced glycogen synthase kinase 3β (GSK-3β) protein expression and phosphorylation and increased oxidation of exogenous palmitate. It can be concluded that CD36 enhances glucose transport for lipogenesis in BAT by suppressing GSK-3β and promotes direct palmitate oxidation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
1932-6203
Volume of the periodical
18
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
e0283276
UT code for WoS article
000970963500038
EID of the result in the Scopus database
2-s2.0-85152599418