RNA modification m6Am: the role in cardiac biology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00573684" target="_blank" >RIV/67985823:_____/23:00573684 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/23:10476108

Result on the web

<a href="https://doi.org/10.1080/15592294.2023.2218771" target="_blank" >https://doi.org/10.1080/15592294.2023.2218771</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15592294.2023.2218771" target="_blank" >10.1080/15592294.2023.2218771</a>

Result language

angličtina

Original language name

RNA modification m6Am: the role in cardiac biology

Original language description

Epitranscriptomic modifications have recently emerged into the spotlight of researchers due to their vast regulatory effects on gene expression and thereby cellular physiology and pathophysiology. N6,2‘-O-dimethyladenosine (m6Am) is one of the most prevalent chemical marks on RNA and is dynamically regulated by writers (PCIF1, METTL4) and erasers (FTO). The presence or absence of m6Am in RNA affects mRNA stability, regulates transcription, and modulates pre-mRNA splicing. Nevertheless, its functions in the heart are poorly known. This review summarizes the current knowledge and gaps about m6Am modification and its regulators in cardiac biology. It also points out technical challenges and lists the currently available techniques to measure m6Am. A better understanding of epitranscriptomic modifications is needed to improve our knowledge of the molecular regulations in the heart which may lead to novel cardioprotective strategies.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epigenetics

ISSN

1559-2294

e-ISSN

1559-2308

Volume of the periodical

18

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

2218771

UT code for WoS article

001009873400001

EID of the result in the Scopus database

2-s2.0-85163163727