The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00583021" target="_blank" >RIV/67985823:_____/24:00583021 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10477858
Result on the web
<a href="https://doi.org/10.3389/fmolb.2024.1327014" target="_blank" >https://doi.org/10.3389/fmolb.2024.1327014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmolb.2024.1327014" target="_blank" >10.3389/fmolb.2024.1327014</a>
Alternative languages
Result language
angličtina
Original language name
The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways
Original language description
Cell signaling regulates several physiological processes by receiving, processing, and transmitting signals between the extracellular and intracellular environments. In signal transduction, phosphorylation is a crucial effector as the most common posttranslational modification. Selectively recognizing specific phosphorylated motifs of target proteins and modulating their functions through binding interactions, the yeast 14-3-3 proteins Bmh1 and Bmh2 are involved in catabolite repression, carbon metabolism, endocytosis, and mitochondrial retrograde signaling, among other key cellular processes. These conserved scaffolding molecules also mediate crosstalk between ubiquitination and phosphorylation, the spatiotemporal control of meiosis, and the activity of ion transporters Trk1 and Nha1. In humans, deregulation of analogous processes triggers the development of serious diseases, such as diabetes, cancer, viral infections, microbial conditions and neuronal and age-related diseases. Accordingly, the aim of this review article is to provide a brief overview of the latest findings on the functions of yeast 14-3-3 proteins, focusing on their role in modulating the aforementioned processes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
<a href="/en/project/GA23-04686S" target="_blank" >GA23-04686S: The role of calcium and 14-3-3 protein in the regulation of human ubiquitin ligase Nedd4-2</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in molecular biosciences
ISSN
2296-889X
e-ISSN
2296-889X
Volume of the periodical
11
Issue of the periodical within the volume
Jan 24
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1327014
UT code for WoS article
001157336400001
EID of the result in the Scopus database
2-s2.0-85184217430