Oxylipin profiling for clinical research: Current status and future perspectives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00587350" target="_blank" >RIV/67985823:_____/24:00587350 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.plipres.2024.101276" target="_blank" >https://doi.org/10.1016/j.plipres.2024.101276</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.plipres.2024.101276" target="_blank" >10.1016/j.plipres.2024.101276</a>
Alternative languages
Result language
angličtina
Original language name
Oxylipin profiling for clinical research: Current status and future perspectives
Original language description
Oxylipins are potent lipid mediators with increasing interest in clinical research. They are usually measured in systemic circulation and can provide a wealth of information regarding key biological processes such as inflammation, vascular tone, or blood coagulation. Although procedures still require harmonization to generate comparable oxylipin datasets, performing comprehensive profiling of circulating oxylipins in large studies is feasible and no longer restricted by technical barriers. However, it is essential to improve and facilitate the biological interpretation of complex oxylipin profiles to truly leverage their potential in clinical research. This requires regular updating of our knowledge about the metabolism and the mode of action of oxylipins, and consideration of all factors that may influence circulating oxylipin profiles independently of the studied disease or condition. This review aims to provide the readers with updated and necessary information regarding oxylipin metabolism, their different forms in systemic circulation, the current limitations in deducing oxylipin cellular effects from in vitro bioactivity studies, the biological and technical confounding factors needed to consider for a proper interpretation of oxylipin profiles.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Progress in Lipid Research
ISSN
0163-7827
e-ISSN
1873-2194
Volume of the periodical
95
Issue of the periodical within the volume
July
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
101276
UT code for WoS article
001249873700001
EID of the result in the Scopus database
2-s2.0-85194874371