In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, Zn alloying and polymer coating

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00587722" target="_blank" >RIV/67985823:_____/24:00587722 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/24:00587722 RIV/67985891:_____/24:00587722 RIV/68407700:21340/24:00376025 RIV/00216208:11110/24:10481650 and 2 more
Result on the web
<a href="https://hdl.handle.net/11104/0354828" target="_blank" >https://hdl.handle.net/11104/0354828</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jma.2024.06.003" target="_blank" >10.1016/j.jma.2024.06.003</a>

Result language
angličtina
Original language name
In vivo and in vitro study of resorbable magnesium wires for medical implants: Mg purity, surface quality, Zn alloying and polymer coating
Original language description
Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone formation. Utilizing low-alloyed Mg-Zn wires can strongly reduce problems with large H2 bubbles and improve the mechanical properties. Acidic pickling and a polymer coating can be effectively used to lower the rate of in vivo degradation. In this work, microstructural, mechanical, and in vitro characterization of 250 µm and 300 µm extruded wires made from ultra-pure Mg, commercially pure Mg, Mg-0.15Zn, Mg-0.4Zn and Mg-1Zn was performed. Additionally, Mg-0.4Zn wires together with a variant coated with a copolymer of l-lactide and ε-caprolactone were tested in vivo on artificially damaged Wistar rat femurs. Based on the observed Mg-induced osteogenesis, polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications, such as cerclage and fixation wires.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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