Faster postnatal decline in hepatic erythropoiesis than granulopoiesis in human newborns
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F25%3A00636208" target="_blank" >RIV/67985823:_____/25:00636208 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10498616 RIV/00216208:11120/25:43928571 RIV/00216208:11310/25:10498616 RIV/00064173:_____/25:43928571 RIV/00064165:_____/25:10498616
Result on the web
<a href="https://doi.org/10.3389/fped.2025.1572836" target="_blank" >https://doi.org/10.3389/fped.2025.1572836</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fped.2025.1572836" target="_blank" >10.3389/fped.2025.1572836</a>
Alternative languages
Result language
angličtina
Original language name
Faster postnatal decline in hepatic erythropoiesis than granulopoiesis in human newborns
Original language description
Background During human foetal development, the liver is the primary site of blood cell production, but this activity declines in the third trimester and postnatally as haematopoiesis shifts to bone marrow. In humans, this postnatal decline is not well characterized due to the scarcity of appropriate samples.Objective To characterize the effect of (i) gestational age at birth and (ii) length of survival after birth on hepatic haematopoiesis across various cell lineages involved.Methods Liver autopsy samples from 25 born-alive infants, predominantly extremely preterm newborns who died mainly between 1 day and 3 weeks after birth, were analysed. Haematopoiesis was characterized using immunohistochemical staining of established cell type-specific protein markers. RNA-sequencing data from our previous study using the same samples were also explored.Results Haematopoiesis negatively correlates with both the duration of prenatal development and the length of postnatal survival. The effect of these two factors varies across different haematopoietic cell lineages. Prenatally and early postnatally, erythropoietic cells dominated hepatic haematopoiesis but were rapidly suppressed within three days after birth. Granulopoietic activity declined more gradually after birth. Analysis of the gene expression data revealed the possible involvement of several transcription factors in lineage-specific regulatory mechanisms.Conclusion This study enhances our understanding of the postnatal decline of hepatic haematopoiesis in human newborns, highlighting the differential regulation of erythropoiesis and granulopoiesis after birth. These factors bring new in-depth knowledge about the biological processes critical for postnatal adaptation of human newborns.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/NU20-07-00026" target="_blank" >NU20-07-00026: Changes of transcriptome during early postnatal development in humans: impact of premature birth on control of energy metabolism</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Pediatrics
ISSN
2296-2360
e-ISSN
2296-2360
Volume of the periodical
13
Issue of the periodical within the volume
20 May
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1572836
UT code for WoS article
001500206100001
EID of the result in the Scopus database
2-s2.0-105007148731