Why has nature invented three stop codons of DNA and only one start codon?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985840%3A_____%2F12%3A00376822" target="_blank" >RIV/67985840:_____/12:00376822 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/12:12777
Result on the web
<a href="http://dx.doi.org/10.1016/j.jtbi.2012.03.026" target="_blank" >http://dx.doi.org/10.1016/j.jtbi.2012.03.026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jtbi.2012.03.026" target="_blank" >10.1016/j.jtbi.2012.03.026</a>

Result language
angličtina
Original language name
Why has nature invented three stop codons of DNA and only one start codon?
Original language description
We examine the standard genetic code with three stop codons. Assuming that the synchronization period of length 3 in DNA or RNA is violated during the transcription or translation processes, the probability of reading a frameshifted stop codon is higherthan if the code would have only one stop codon. Consequently, the synthesis of RNA or proteins will soon terminate. In this way, cells do not produce undesirable proteins and essentially save energy. This hypothesis is tested on the AT-rich Drosophila genome, where the detection of frameshifted stop codons is even higher than the theoretical value. Using the binomial theorem, we establish the probability of reading a frameshifted stop codon within n steps. Since the genetic code is largely redundant, there is still space for some hidden secondary functions of this code.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)