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Markers of Lipid Oxidative Damage in the Exhaled Breath Condensate of Nano TiO2 Production Workers.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F17%3A00470937" target="_blank" >RIV/67985858:_____/17:00470937 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388955:_____/17:00470937 RIV/00216208:11110/17:10361865 RIV/00216208:11510/17:10361865 RIV/60461373:22310/17:43902833 RIV/00064165:_____/17:10361865

  • Result on the web

    <a href="http://dx.doi.org/10.1080/17435390.2016.1262921" target="_blank" >http://dx.doi.org/10.1080/17435390.2016.1262921</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/17435390.2016.1262921" target="_blank" >10.1080/17435390.2016.1262921</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Markers of Lipid Oxidative Damage in the Exhaled Breath Condensate of Nano TiO2 Production Workers.

  • Original language description

    Nanoscale titanium dioxide (nanoTiO2) is a commercially important nanomaterial. Animal studies have documented lung injury and inflammation, oxidative stress, cytotoxicity and genotoxicity. Yet human health data are scarce and quantitative risk assessments and biomonitoring of exposure are lacking. NanoTiO2 is classified by IARC as a group 2B, possible human carcinogen. In our earlier studies we documented an increase in markers of inflammation, as well as DNA and protein oxidative damage, in exhaled breath condensate (EBC) of workers exposed nanoTiO2. This study focuses on biomarkers of lipid oxidation. Several established lipid oxidative markers (malondialdehyde, 4-hydroxy-trans-hexenal, 4-hydroxy-trans-nonenal, 8-isoProstaglandin F2α and aldehydes C6-C12) were studied in EBC and urine of 34 workers and 45 comparable controls. The median particle number concentration in the production line ranged from 1.98x104 to 2.32x104 particles/cm3 with ∼80% of the particles <100 nm in diameter. Mass concentration varied between 0.40-0.65 mg/m3. All 11 markers of lipid oxidation were elevated in production workers relative to the controls (p < 0.001). A significant dose-dependent association was found between exposure to TiO2 and markers of lipid oxidation in the EBC. These markers were not elevated in the urine samples. Lipid oxidation in the EBC of workers exposed to (nano)TiO2 complements our earlier findings on DNA and protein damage. These results are consistent with the oxidative stress hypothesis and suggest lung injury at the molecular level. Further studies should focus on clinical markers of potential disease progression. EBC has reemerged as a sensitive technique for non-invasive monitoring of workers exposed to engineered nanoparticles.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30304 - Public and environmental health

Result continuities

  • Project

    <a href="/en/project/GBP503%2F12%2FG147" target="_blank" >GBP503/12/G147: Centre for studies on toxicity of nanoparticles</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nanotoxicology

  • ISSN

    1743-5390

  • e-ISSN

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    52-63

  • UT code for WoS article

    000394718700006

  • EID of the result in the Scopus database

    2-s2.0-85003828452