Microfluidic Chip Reactor and the Stereoselective Hydrogenation of Methylacetoacetate over (R)-Ru-BINAP in the [N8222][Tf2N]/Methanol/ Water Mixed Phase.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F17%3A00474317" target="_blank" >RIV/67985858:_____/17:00474317 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/17:10359902

Result on the web

<a href="http://dx.doi.org/10.1016/j.cep.2017.02.002" target="_blank" >http://dx.doi.org/10.1016/j.cep.2017.02.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cep.2017.02.002" target="_blank" >10.1016/j.cep.2017.02.002</a>

Result language

angličtina

Original language name

Microfluidic Chip Reactor and the Stereoselective Hydrogenation of Methylacetoacetate over (R)-Ru-BINAP in the [N8222][Tf2N]/Methanol/ Water Mixed Phase.

Original language description

Homogeneous asymmetric catalysts represented by organometallics of transition elements reveal very high activity and stereoselectivity in asymmetric hydrogenation of b-ketoesters. Recently, it appeared efficient to use ionic liquids of the [NR222][Tf2N] type for accommodation of the chiral catalytic complex. Even on the industrial scale it is becoming attractive to carry out hydrogenations with such immobilised complexes in a continuous regime in microreactors. Attention was paid to the stereoselective hydrogenation of methylacetoacetate (MAA) to isomeric (R)_(+) or (S)_(_)-methyl-3-hydroxybuta- noates over a chiral ([RuCl((R)-BINAP)(p-cymene)]Cl) complex immobilised in the mixed [N8222][Tf2N]/ methanol/water solvent phase, and performed inside of a microfluidic chip reactor. It was shown that the reaction could be successfully carried out in such an arrangement with a very high enantioselectivity (above 99%) and at very high conversion of MAA (above 97%). It was proven that the participation of a specific solvent (methanol or the mixture [N8222][Tf2N]/methanol/water) essentially influences the mechanism of the reaction. The solvents actively participate in the re-coordination of the catalytic complex in a series of reactions which is reflected in the values of reaction enthalpies. The specific process output was also evaluated.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20402 - Chemical process engineering

Project

<a href="/en/project/GA15-04790S" target="_blank" >GA15-04790S: Assymetric Hydrogenations with Chiral Complexes in Ionic Liquids - Reaction Engineering Aspects</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Engineering and Processing: Process Intensification

ISSN

0255-2701

e-ISSN

—

Volume of the periodical

115

Issue of the periodical within the volume

May

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

39-46

UT code for WoS article

000399850500005

EID of the result in the Scopus database

2-s2.0-85013477778