Design of the reversible biphasic arrangement in the microfluidic chip reactor for asymmetric hydrogenation reactions.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F20%3A00518838" target="_blank" >RIV/67985858:_____/20:00518838 - isvavai.cz</a>

Alternative codes found

RIV/44555601:13520/20:43894957 RIV/00216208:11310/20:10408115

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0263876219305490?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0263876219305490?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cherd.2019.11.023" target="_blank" >10.1016/j.cherd.2019.11.023</a>

Result language

angličtina

Original language name

Design of the reversible biphasic arrangement in the microfluidic chip reactor for asymmetric hydrogenation reactions.

Original language description

Design of the reversible biphasic system for a practical use in asymmetric hydrogenation performed in a microfluidic chip reactor is reported. Methylacetoacetate (MAA) was transformed to (R)-methylhydroxybutyrate over optically pure (R)-Ru-BINAP as a model reaction. The study was an iteration towards the design, description and optimization of the temperature driven reversible biphasic system in the mixed [NR,222][Tf2N]/methanol/water phase by varying the parameter of the structure of the ionic molecule, starting from [NH4][Tf2N] up to [N14,222][Tf2N]. At temperatures, and other conditions providing high conversions and optical yields, the reaction mixture was monophasic. At lower temperatures, the mixture became biphasic for ionic liquids with long alkyl chains (namely [N14,222][Tf2N]) due to their strong non-polar character. The formed ionic liquid phase accommodated the chiral Ru complex, the water/methanol phase the reaction products. After the reaction, when the mixture was cooled, over 90% of the catalytic complex was kept in the ionic liquid phase. Viscosity and density data were also discussed. It seems the reversible biphasic system offers a way to facilitate the separation of the chiral Ru-complex from the reaction mixture. Due to high sensitivity of the complex to handling conditions, its reuse still requires further optimization.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20402 - Chemical process engineering

Project

<a href="/en/project/GA15-04790S" target="_blank" >GA15-04790S: Assymetric Hydrogenations with Chiral Complexes in Ionic Liquids - Reaction Engineering Aspects</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Engineering Research and Design

ISSN

0263-8762

e-ISSN

—

Volume of the periodical

153

Issue of the periodical within the volume

January

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

537-546

UT code for WoS article

000510526400045

EID of the result in the Scopus database

2-s2.0-85075591042