ESI-TOF Mass Spectrometry of Cationic Carbosilane Dendrimers: a Potent Tool for Characterization of Structural Defects.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F18%3A00494758" target="_blank" >RIV/67985858:_____/18:00494758 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jms.4269" target="_blank" >http://dx.doi.org/10.1002/jms.4269</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jms.4269" target="_blank" >10.1002/jms.4269</a>
Alternative languages
Result language
angličtina
Original language name
ESI-TOF Mass Spectrometry of Cationic Carbosilane Dendrimers: a Potent Tool for Characterization of Structural Defects.
Original language description
Macromolecular polyelectrolytes are gaining considerable attention for the application in medicine which implies their detailed characterization. We have successfully applied electrospray ionization mass spectrometry (ESI MS) to the analysis of defects in the structure of three generations of polycationic carbosilane dendrimers bearing series of quarternary phosphonium groups at their periphery. Besides expected defects caused by incomplete conversion of particular reaction steps during the synthesis of dendritic scaffold and subsequent peripheral functionalization, also several products of side reactions were observed together with defects created in the course of measurement (particularly ion exchange products). Defective molecules can be to some extent separated on GPC column which proves that they are not products of in source fragmentation processes. Within the reaction sequence used for the synthesis of dendrimers under study, hydrosilylation was the source of most defects. The effectivity of quarternization depends on the type of phosphine. Results confirm high sensitivity of ESI MS towards defects, stability of the carbosilane skeleton towards fragmentation under the conditions of ESI ionization and capability to detect both lower‐ and higher molecular weight impurities arising from the synthetic sequence in the same m/z range as the target dendrimer, thus providing valuable view of the polydispersity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GA15-05903S" target="_blank" >GA15-05903S: Novel carbosilane dendrimers for biomedical applications - interactions with biomolecules and biomembranes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Mass Spectrometry
ISSN
1076-5174
e-ISSN
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Volume of the periodical
53
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
986-996
UT code for WoS article
000446836600010
EID of the result in the Scopus database
2-s2.0-85052430394