Pervaporation of (R)/(S)-Methyl 3-Hydroxybutyrate (∑MHB) from a Mixture Containing an Ionic Liquid, Methanol and Ru Catalyst.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F19%3A00503819" target="_blank" >RIV/67985858:_____/19:00503819 - isvavai.cz</a>

Result on the web

<a href="http://hdl.handle.net/11104/0295889" target="_blank" >http://hdl.handle.net/11104/0295889</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.seppur.2019.04.017" target="_blank" >10.1016/j.seppur.2019.04.017</a>

Result language

angličtina

Original language name

Pervaporation of (R)/(S)-Methyl 3-Hydroxybutyrate (∑MHB) from a Mixture Containing an Ionic Liquid, Methanol and Ru Catalyst.

Original language description

Complex technologies in the production of fine chemicals bring together various connected processes, each bringing specific green chemistry challenges. A valuable mixture arises in the stereoselective hydrogenation of methyl-acetoacetate (MAA) to (R)- and (S)- methyl 3-hydroxybutyrate (∑MHB) over Ru organometallic complex (R)-Ru/BINAP, and in a green tetra-alkylammonium bistriflimide/methanol/water solvent phase. The reaction could be carried out in various arrangements, e.g. in a batch mode, in a continuous stirred-tank reactor, or even in a tubular microfluidic chip reactor. In either case, the valuable optically pure Ru complex has been sought to be effectively separated, and potentially recycled. The ionic liquid phase (tetra-alkylammonium bistriflimide) is intended for selective accommodation of the complex in the reaction mixture and as a green alternative to other solvents. It was the main issue of this work to design a specific separation unit, to construct it, and to optimize its performance towards the efficient separation of ∑MHB from the ionic liquid phase bearing the (R)-Ru/BINAP complex. The unit was developed to be connected with the complex preparation process, employing the microreactor fluid flow platform. The separation part of the overall technology was designed as a membrane pervaporation. The membrane separation proceeded with different feed mixtures combining ∑methyl 3-hydroxybutyrate, methanol, ionic liquid and/or the catalyst. The technique was applied at various temperatures, using the industrial composite PDMS membrane, PERVAP™ 4060 from Sulzer. The feed as well as the pervaporate were analyzed by nuclear magnetic resonance spectroscopy and infrared spectroscopy. The enrichment factor of the ∑MHB with respect to the retentate was 1.24 and the ∑MHB permeate mass flux was 61 g h −1 m −2 . In addition, the membrane was characterized by scanning electron microscopy and energy dispersive X-ray microanalysis after the membrane process, showing no sorption of the catalyst into the membrane.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20402 - Chemical process engineering

Project

<a href="/en/project/GA17-00089S" target="_blank" >GA17-00089S: Separation of Racemic Mixtures by Membrane Processes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Separation and Purification Technology

ISSN

1383-5866

e-ISSN

—

Volume of the periodical

222

Issue of the periodical within the volume

SEP 1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

45-52

UT code for WoS article

000468714100006

EID of the result in the Scopus database

2-s2.0-85064075206