Effects of Workers Exposure to Nanoparticles Studied by NMR Metabolomics.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F21%3A00544564" target="_blank" >RIV/67985858:_____/21:00544564 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10429727 RIV/00064165:_____/21:10429727 RIV/46747885:24210/21:00009176
Result on the web
<a href="https://www.mdpi.com/2076-3417/11/14/6601" target="_blank" >https://www.mdpi.com/2076-3417/11/14/6601</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/app11146601" target="_blank" >10.3390/app11146601</a>

Result language
angličtina
Original language name
Effects of Workers Exposure to Nanoparticles Studied by NMR Metabolomics.
Original language description
In this study, the effects of occupational exposure to nanoparticles (NPs) were studied by NMR metabolomics. Exhaled breath condensate (EBC) and blood plasma samples were obtained from a research nanoparticles-processing unit at a national research university. The samples were taken from three groups of subjects: samples from workers exposed to nanoparticles collected before and after shift, and from controls not exposed to NPs. Altogether, 601H NMR spectra of exhaled breath condensate (EBC) samples and 601H NMR spectra of blood plasma samples were analysed, 20 in each group. The metabolites identified together with binning data were subjected to multivariate statistical analysis, which provided clear discrimination of the groups studied. Statistically sig-nificant metabolites responsible for group separation served as a foundation for analysis of im-paired metabolic pathways. It was found that the acute effect of NPs exposure is mainly reflected in the pathways related to the production of antioxidants and other protective species, while the chronic effect is manifested mainly in the alteration of glutamine and glutamate metabolism, and the purine metabolism pathway.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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