Binaphthalene-based cyclic homochiral ureas and their structure-related properties

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F23%3A00570922" target="_blank" >RIV/67985858:_____/23:00570922 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/23:43927884
Result on the web
<a href="https://pubs.rsc.org/en/content/articlepdf/2023/nj/d2nj06147c" target="_blank" >https://pubs.rsc.org/en/content/articlepdf/2023/nj/d2nj06147c</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D2NJ06147C" target="_blank" >10.1039/D2NJ06147C</a>

Result language
angličtina
Original language name
Binaphthalene-based cyclic homochiral ureas and their structure-related properties
Original language description
Enantiomeric purity control is a must when working with chiral drugs. In this context, homochiral cycles consisting solely of 1 to 3 binaphthalene units interconnected with urea moieties were tested as chiral solvating agents for enantiomers of naproxen. Among the tested compounds, only the dimeric structure formed stable diastereomeric complexes with naproxen with KR = 43±3 M-1/ Ks = 34±2 M-1. When the conformational mobility of the dimer was decelerated by cooling to -30 °C, the complexes became stronger (KR-30 = 100±6 M-1/ KS-30 = 102±7 M-1). Using DFT calculation, probable structures of the diastereomeric complex were proposed.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GA20-07833S" target="_blank" >GA20-07833S: New nanomaterials for anion separation</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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