Safety assessment and redox status in rats after chronic exposure to cannabidiol and cannabigerol

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F23%3A00571687" target="_blank" >RIV/67985858:_____/23:00571687 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00130557 RIV/61989592:15110/23:73621805 RIV/61989592:15310/23:73621805 RIV/00159816:_____/23:00078772

Result on the web

<a href="https://hdl.handle.net/11104/0342735" target="_blank" >https://hdl.handle.net/11104/0342735</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tox.2023.153460" target="_blank" >10.1016/j.tox.2023.153460</a>

Result language

angličtina

Original language name

Safety assessment and redox status in rats after chronic exposure to cannabidiol and cannabigerol

Original language description

Cannabidiol (CBD) and cannabigerol (CBG) are the two main non-psychotropic phytocannabinoids with high application potential in drug development. Both substances are redox-active and are intensively investigated for their cytoprotective and antioxidant action in vitro. In this study, we focused on an in vivo safety evaluation and the effect of CBD and CBG on the redox status in rats in a 90-d experiment. The substances were administered orogastrically in a dose of 0.66 mg synthetic CBD or 0.66 mg/1.33 mg CBG/kg/day. CBD produced no changes in the red or white blood count or biochemical blood parameters in comparison to the control. No deviations in the morphology or histology of the gastrointestinal tract and liver were observed. After 90 d of CBD exposure, a significant improvement in redox status was found in the blood plasma and liver. The concentration of malondialdehyde and carbonylated proteins was reduced compared to the control. In contrast to CBD, total oxidative stress was significantly increased and this was accompanied by an elevated level of malondialdehyde and carbonylated proteins in CBG-treated animals. Hepatotoxic (regressive changes) manifestations, disruption in white cell count, and alterations in the ALT activity, level of creatinine and ionized calcium were also found in CBG-treated animals. Based on liquid chromatography-mass spectrometry analysis, CBD/CBG accumulated in rat tissues (in the liver, brain, muscle, heart, kidney and skin) at a low ng level per gram. Both CBD and CBG molecular structures include a resorcinol moiety. In CBG, there is an extra dimethyloctadienyl structural pattern, which is most likely responsible for the disruption to the redox status and hepatic environment. The results are valuable to further investigation of the effects of CBD on redox status and should contribute towards opening up critical discussion on the applicability of other non-psychotropic cannabinoids.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30108 - Toxicology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology

ISSN

0300-483X

e-ISSN

—

Volume of the periodical

488

Issue of the periodical within the volume

APR 2023

Country of publishing house

IE - IRELAND

Number of pages

10

Pages from-to

153460

UT code for WoS article

000962570900001

EID of the result in the Scopus database

2-s2.0-85150665747