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Safety assessment and redox status in rats after chronic exposure to cannabidiol and cannabigerol

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F23%3A00571687" target="_blank" >RIV/67985858:_____/23:00571687 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/23:00130557 RIV/61989592:15110/23:73621805 RIV/61989592:15310/23:73621805 RIV/00159816:_____/23:00078772

  • Result on the web

    <a href="https://hdl.handle.net/11104/0342735" target="_blank" >https://hdl.handle.net/11104/0342735</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.tox.2023.153460" target="_blank" >10.1016/j.tox.2023.153460</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Safety assessment and redox status in rats after chronic exposure to cannabidiol and cannabigerol

  • Original language description

    Cannabidiol (CBD) and cannabigerol (CBG) are the two main non-psychotropic phytocannabinoids with high application potential in drug development. Both substances are redox-active and are intensively investigated for their cytoprotective and antioxidant action in vitro. In this study, we focused on an in vivo safety evaluation and the effect of CBD and CBG on the redox status in rats in a 90-d experiment. The substances were administered orogastrically in a dose of 0.66 mg synthetic CBD or 0.66 mg/1.33 mg CBG/kg/day. CBD produced no changes in the red or white blood count or biochemical blood parameters in comparison to the control. No deviations in the morphology or histology of the gastrointestinal tract and liver were observed. After 90 d of CBD exposure, a significant improvement in redox status was found in the blood plasma and liver. The concentration of malondialdehyde and carbonylated proteins was reduced compared to the control. In contrast to CBD, total oxidative stress was significantly increased and this was accompanied by an elevated level of malondialdehyde and carbonylated proteins in CBG-treated animals. Hepatotoxic (regressive changes) manifestations, disruption in white cell count, and alterations in the ALT activity, level of creatinine and ionized calcium were also found in CBG-treated animals. Based on liquid chromatography-mass spectrometry analysis, CBD/CBG accumulated in rat tissues (in the liver, brain, muscle, heart, kidney and skin) at a low ng level per gram. Both CBD and CBG molecular structures include a resorcinol moiety. In CBG, there is an extra dimethyloctadienyl structural pattern, which is most likely responsible for the disruption to the redox status and hepatic environment. The results are valuable to further investigation of the effects of CBD on redox status and should contribute towards opening up critical discussion on the applicability of other non-psychotropic cannabinoids.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30108 - Toxicology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Toxicology

  • ISSN

    0300-483X

  • e-ISSN

  • Volume of the periodical

    488

  • Issue of the periodical within the volume

    APR 2023

  • Country of publishing house

    IE - IRELAND

  • Number of pages

    10

  • Pages from-to

    153460

  • UT code for WoS article

    000962570900001

  • EID of the result in the Scopus database

    2-s2.0-85150665747