Zeolite-based chiral ion-exchangers for chromatographic enantioseparations and potential applications in membrane separation processes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F24%3A00588264" target="_blank" >RIV/67985858:_____/24:00588264 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/24:43929113 RIV/60461373:22330/24:43929113 RIV/60461373:22340/24:43929113 RIV/00216208:11310/24:10481910
Result on the web
<a href="https://hdl.handle.net/11104/0355202" target="_blank" >https://hdl.handle.net/11104/0355202</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.talanta.2024.126419" target="_blank" >10.1016/j.talanta.2024.126419</a>
Alternative languages
Result language
angličtina
Original language name
Zeolite-based chiral ion-exchangers for chromatographic enantioseparations and potential applications in membrane separation processes
Original language description
Chiral resolution of racemic compounds represents an important task in research and development and, most importantly, in the large-scale production of pharmaceuticals. Zeolites, which are already frequently utilized for their unique properties, represent materials that can be used for the development of new chiral stationary phases for liquid chromatography, simulated moving bed or enantioselective membranes. The aim of this study was to modify a series of MWW zeolites by a chiral anion-exchange type selector thereby creating a chiral stationary phase for enantiomeric resolution of acidic compounds. To evaluate the applicability of the prepared chiral stationary phase in liquid chromatography, we used N-protected amino acids as model analytes. First, we tested the new sorbents preferential sorption using N-(3,5-dinitrobenzoyl)leucine. We observed outstanding sorption properties of a zeolite-based sorbent (MCM-36), which were comparable to spherical chromatographic silica. This particular material was subsequently packed into a chromatographic column, which was tested under polar organic mode HPLC conditions facilitating baseline resolution of 5 out of 8 N-protected amino acids. Although the chromatographic performance shows several drawbacks (high backpressure, low column efficiency), it clearly documents the potential of the novel materials in chiral separation. To the best of our knowledge, this is the first example of the preparation of the chiral stationary phase based on MWW zeolites ever.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20402 - Chemical process engineering
Result continuities
Project
<a href="/en/project/GA23-06152S" target="_blank" >GA23-06152S: Modular approach towards chiral membranes for scalable enantioseparation of racemic drugs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Talanta
ISSN
0039-9140
e-ISSN
1873-3573
Volume of the periodical
278
Issue of the periodical within the volume
OCT 1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
126419
UT code for WoS article
001259499400001
EID of the result in the Scopus database
2-s2.0-85186115278