Dissipative particle dynamics as a computational tool to detect the morphology-rheology interplay in Pluronic F68/water mixtures: A promising drug carrier
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F25%3A00640410" target="_blank" >RIV/67985858:_____/25:00640410 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0021979725019162" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0021979725019162</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcis.2025.138525" target="_blank" >10.1016/j.jcis.2025.138525</a>
Alternative languages
Result language
angličtina
Original language name
Dissipative particle dynamics as a computational tool to detect the morphology-rheology interplay in Pluronic F68/water mixtures: A promising drug carrier
Original language description
Pluronics, also known as poloxamers, are amphiphilic triblock copolymers widely employed in drug delivery systems due to their tunable self-assembly and biocompatibility. Among them, Pluronic F68 (Poloxamer 188) exhibits thermoresponsive behavior in aqueous solution, forming ordered supramolecular structures at high concentrations and temperatures. In this work, we investigate the morphological and rheological properties of a 45 wt% Pluronic F68 aqueous system at different temperatures through a combination of experimental and computational approaches. Rheological measurements and Small-Angle X-ray Scattering (SAXS) confirm the formation of a body-centered cubic (BCC) structure at higher temperatures and highlight the emergence of viscoelastic solid-like behavior. To support and extend these findings, Dissipative Particle Dynamics (DPD) simulations are employed to model the nanostructure evolution and the impact of temperature on self-assembly and material properties. This integrated approach provides a consistent framework to characterize the temperature-induced transition from fluid-like to solid-like states and sets the groundwork for future simulation studies incorporating drug cargo. The results offer valuable insights into the design of thermoresponsive drug delivery systems and demonstrate the potential of DPD in capturing complex structure–property relationships in amphiphilic polymer systems.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Colloid and Interface Science
ISSN
0021-9797
e-ISSN
1095-7103
Volume of the periodical
700
Issue of the periodical within the volume
DEC 15 2025
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
138525
UT code for WoS article
001614920000017
EID of the result in the Scopus database
2-s2.0-105012258568