Drinking water quality assessment by nontargeted analysis and human cytochrome P450 3A enzyme activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985874%3A_____%2F26%3A00645631" target="_blank" >RIV/67985874:_____/26:00645631 - isvavai.cz</a>

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acsestwater.5c01298" target="_blank" >https://pubs.acs.org/doi/10.1021/acsestwater.5c01298</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsestwater.5c01298" target="_blank" >10.1021/acsestwater.5c01298</a>

Result language

angličtina

Original language name

Drinking water quality assessment by nontargeted analysis and human cytochrome P450 3A enzyme activity

Original language description

Drinking water treatment plants (DWTPs) are primarily not designed to eliminate emerging organic contaminants, hence plenty of compounds are frequently determined in drinking waters, leading to unknown risks for human health. Nontarget analysis (NTA) combined with bioassays can provide a detailed assessment of water quality and treatment performance. In this study, an NTA andnhuman cytochrome P450 3A (CYP3A) enzyme activity assay was conducted for raw and treated water samples from three DWTPs located within the Czech Republic. The results revealed significant mutual differences in the quality of raw and treated waters between the DWTPs. Although many compounds were apparently removed, additional features (51−72) were detected in treated water,nindicating that transformation products might have been formed. Additionally, two potential disinfection byproducts were determined. Furthermore, dozens of chemicals were tentatively identified in raw and treated waters with high confidence at level 2, mostly pharmaceuticals, pesticides, and their respective metabolites. The enzyme activity of CYP3A was significantly inhibited in raw water samples from all DWTPs and in one treated water sample. These findings were in line with the results obtained from nontargeted analysis. The present findings demonstrate the usefulness of the CYP3A enzyme activity in revealing the possible impact on xenobiotic metabolism in DWTPs.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

<a href="/en/project/TN02000069" target="_blank" >TN02000069: National centre of competence for Materials, Advanced Technologies, Coatings and their Applications</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2026

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS ES&T Water

ISSN

2690-0637

e-ISSN

2690-0637

Volume of the periodical

6

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

1929-1304

UT code for WoS article

001683942400001

EID of the result in the Scopus database

2-s2.0-105030053866