Deformability of Microtubules: An Atomistic Computational Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F16%3A00473505" target="_blank" >RIV/67985882:_____/16:00473505 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Deformability of Microtubules: An Atomistic Computational Study

Original language description

Thanks to their material properties, microtubules can play complex variety of biological functions. Experimental studies have shown that mechanical characteristics of microtubules are length-dependent and anisotropic, however, the origin of this feature has not been traced down to the level of tubulin sequence yet. Here we use high-resolution elastic network model to show local deformations patterns in microtubule structure up to the level of individual amino acid residues. The mechanical strain within the molecular structure of a microtubule is, according to our results, localized to interdimer contacts with energetic preference of deformation in longitudinal contacts. These findings are in agreement with reported mechanical anisotropy of microtubules, i.e. higher Young's modulus in axial direction compared to radial direction. Our results contribute to understanding the origin of deformability of microtubules on the molecular level, which is important for prospective targeting of microtubules in medical therapeutic strategies

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

JA - Electronics and optoelectronics

OECD FORD branch

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Project

<a href="/en/project/GA15-17102S" target="_blank" >GA15-17102S: Radio-frequency characterization of microtubules using micro- and nanosensors</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů