Deformation pattern in vibrating microtubule: Structural mechanics study based on an atomistic approach

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F17%3A00508136" target="_blank" >RIV/86652036:_____/17:00508136 - isvavai.cz</a>
Alternative codes found
RIV/67985882:_____/17:00484845
Result on the web
<a href="https://www.nature.com/articles/s41598-017-04272-w" target="_blank" >https://www.nature.com/articles/s41598-017-04272-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-017-04272-w" target="_blank" >10.1038/s41598-017-04272-w</a>

Result language
angličtina
Original language name
Deformation pattern in vibrating microtubule: Structural mechanics study based on an atomistic approach
Original language description
The mechanical properties of microtubules are of great importance for understanding their biological function and for applications in artificial devices. Although microtubule mechanics has been extensively studied both theoretically and experimentally, the relation to its molecular structure is understood only partially. Here, we report on the structural analysis of microtubule vibration modes calculated by an atomistic approach. Molecular dynamics was applied to refine the atomic structure of a microtubule and a C-alpha elastic network model was analyzed for its normal modes. We mapped fluctuations and local deformations up to the level of individual aminoacid residues. The deformation is mode-shape dependent and principally different in alpha-tubulins and beta-tubulins. Parts of the tubulin dimer sequence responding specifically to longitudinal and radial stress are identified. We show that substantial strain within a microtubule is located both in the regions of contact between adjacent dimers and in the body of tubulins. Our results provide supportive evidence for the generally accepted assumption that the mechanics of microtubules, including its anisotropy, is determined by the bonds between tubulins.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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