gamma-Tubulin in microtubule nucleation and beyond
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00562229" target="_blank" >RIV/68378050:_____/22:00562229 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3389/fcell.2022.880761" target="_blank" >https://doi.org/10.3389/fcell.2022.880761</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2022.880761" target="_blank" >10.3389/fcell.2022.880761</a>
Alternative languages
Result language
angličtina
Original language name
gamma-Tubulin in microtubule nucleation and beyond
Original language description
Microtubules composed of alpha betatubulin dimers are dynamic cytoskeletal polymers that play key roles in essential cellular processes such as cell division, organelle positioning, intracellular transport, and cell migration. gammaTubulin is a highly conserved member of the tubulin family that is required for microtubule nucleation. gammaTubulin, together with its associated proteins, forms the gammatubulin ring complex (gammaTuRC), that templates microtubules. Here we review recent advances in the structure of gammaTuRC, its activation, and centrosomal recruitment. This provides new mechanistic insights into the molecular mechanism of microtubule nucleation. Accumulating data suggest that gammatubulin also has other, less well understood functions. We discuss emerging evidence that gammatubulin can form oligomers and filaments, has specific nuclear functions, and might be involved in centrosomal cross-talk between microtubules and microfilaments.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cell and Developmental Biology
ISSN
2296-634X
e-ISSN
2296-634X
Volume of the periodical
10
Issue of the periodical within the volume
Sep 1
Country of publishing house
CH - SWITZERLAND
Number of pages
14
Pages from-to
880761
UT code for WoS article
000859594900001
EID of the result in the Scopus database
2-s2.0-85138809258