Pregnancy-Associated Plasma Protein A2 in Hemodialysis Patients: Significance for Prognosis

Result code in IS VaVaI

RIV/67985882:_____/17:00484778 - isvavai.cz

Alternative codes found

RIV/00216208:11110/17:10362284 RIV/00179906:_____/17:10362284 RIV/00064165:_____/17:10362284

Result on the web

http://dx.doi.org/10.1159/000479847

DOI - Digital Object Identifier

10.1159/000479847

Result language

angličtina

Original language name

Pregnancy-Associated Plasma Protein A2 in Hemodialysis Patients: Significance for Prognosis

Original language description

Background: Pregnancy-associated plasma protein A (PAPP-A) is associated with adverse outcome of long-term hemodialysis patients (HD). The aim of the study was to test whether its homolog pregnancy-associated plasma protein A2 (PAPP-A2) can be detected in serum of HD patients and to define its significance. Methods: The studied group consisted of 102 long-term HD patients and 25 healthy controls. HD patients were prospectively followed up for five years (2009-2014). PAPP-A2 was measured by surface plasmon resonance biosensor, PAPP-A by time resolved amplified cryptate emission. Results: PAPP-A2, similarly as PAPP-A, was significantly increased in HD patients (median (interquartile range)) PAPP-A2: 6.2 (2.6-10.8) ng/mL, vs. 3.0 (0.7-5.9) ng/mL, p=0.006, PAPP-A: 18.9 (14.3-23.4) mIU/L, vs. 9.5 (8.4-10.5) mIU/L, p < 0.001). In HD patients, PAPP-A2 correlated weakly but significantly with PAPP-A (tau=0.193, p=0.004). Unlike PAPP-A, PAPP-A2 was not significant for prognosis of HD patients when tested alone. There was a significant interaction between PAPP-A and PAPP-A2 on the mortality due to infection of HD patients (p=0.008). If PAPP-A was below median, mortality due to infection was significantly higher for patients with PAPP-A2 values above median than for patients with low PAPP-A2 levels (p=0.011). Conclusion: PAPP-A2 is increased in HD patients and interacts with PAPP-A on patients´prognosis

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

GBP205/12/G118: Nanobiophotonics for future health care

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Kidney & Blood Pressure Research

ISSN

1420-4096

e-ISSN

—

Volume of the periodical

42

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

509-518

UT code for WoS article

000414970500011

EID of the result in the Scopus database

2-s2.0-85028768496