Performance of label-free optical biosensors: What is figure of merit (not) telling us?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F22%3A00560103" target="_blank" >RIV/67985882:_____/22:00560103 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.bios.2022.114426" target="_blank" >https://doi.org/10.1016/j.bios.2022.114426</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bios.2022.114426" target="_blank" >10.1016/j.bios.2022.114426</a>

Result language

angličtina

Original language name

Performance of label-free optical biosensors: What is figure of merit (not) telling us?

Original language description

Here we study the analytical performance of label-free optical biosensors with respect to analyte-induced refractive index changes that can be measured by a biosensor (refractive index resolution). We present an analytical model that interrelates the refractive index resolution and the parameters of the optical platform of a biosensor. We demonstrate that the figure of merit (FOM), which has been widely used to design optical platforms of label-free optical biosensors, is not an appropriate metric to guide the design or predict the performance of label-free optical biosensors. Therefore, we propose an extended definition of FOM that addresses its limitations. We confirm the validity of the proposed approach by both numerical simulations and experiments. Finally, we show that the analytical model of the refractive index resolution not only makes it possible to predict the performance of a biosensor but also provides strategies for achieving optimal performance.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10306 - Optics (including laser optics and quantum optics)

Project

<a href="/en/project/GX20-23787X" target="_blank" >GX20-23787X: Novel biophotonic tools for investigation of cellular processes</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biosensors and Bioelectronics

ISSN

0956-5663

e-ISSN

1873-4235

Volume of the periodical

212

Issue of the periodical within the volume

SEP 15

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

114426

UT code for WoS article

000833517400003

EID of the result in the Scopus database

2-s2.0-85131426220