Free-Blockage Mesoporous Silica Nanoparticles Loaded with Cerium Oxide as ROS-Responsive and ROS-Scavenging Nanomedicine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F22%3A00564327" target="_blank" >RIV/67985891:_____/22:00564327 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11320/22:10455645
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/adfm.202208316" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/adfm.202208316</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.202208316" target="_blank" >10.1002/adfm.202208316</a>
Alternative languages
Result language
angličtina
Original language name
Free-Blockage Mesoporous Silica Nanoparticles Loaded with Cerium Oxide as ROS-Responsive and ROS-Scavenging Nanomedicine
Original language description
Mesoporous silica nanoparticles (MSNs) with reactive oxygen species (ROS)-responsive nanogate as drug delivery platforms are extensively investigated for biomedical applications. However, the physical blockages used to control the cargo release are often limited by their poor sealing ability and low biocompatibility. Herein, a design of free-blockage MSNs with methylthiopropyl units is proposed as the ROS-responsive switch. Four synthetic routes are compared with different precursors through either co-condensation or grafting methods to achieve the methylthio-functionalized MSNs. The quantity, localization, and chemical structure of the functional units, as well as the mesoporous structure of the silica can be tuned by optimizing the synthetic pathways to obtain desired final products. The ROS-responsive methylthiopropyl groups can be oxidized to sulfoxides in response to the presence of H2O2, leading to the hydrophobic/hydrophilic conversion of the MSNs. As a proof-of-concept design, ultrasmall cerium oxide nanoparticles are encapsulated into the functionalized MSNs and released out within 10 min scavenging more than 80% of the H2O2 in an ROS-rich environment. This study provides a novel design of a free-blockage ROS-controlled release system loaded with ROS-scavenging nanoparticles for the future application of targeted drug delivery systems combined with antioxidant therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Functional Materials
ISSN
1616-301X
e-ISSN
1616-3028
Volume of the periodical
32
Issue of the periodical within the volume
46
Country of publishing house
DE - GERMANY
Number of pages
21
Pages from-to
2208316
UT code for WoS article
000860643300001
EID of the result in the Scopus database
2-s2.0-85138733240