In Vivo Degradation and Local Tissue Response of Experimental Carp Collagen Membranes: Micro-MRI and Histological Analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F25%3A00639545" target="_blank" >RIV/67985891:_____/25:00639545 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10501047 RIV/00216208:11140/25:10501047 RIV/00064165:_____/25:10501047
Result on the web
<a href="https://doi.org/10.1002/bip.70045" target="_blank" >https://doi.org/10.1002/bip.70045</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/bip.70045" target="_blank" >10.1002/bip.70045</a>
Alternative languages
Result language
angličtina
Original language name
In Vivo Degradation and Local Tissue Response of Experimental Carp Collagen Membranes: Micro-MRI and Histological Analysis
Original language description
Collagen membranes are widely used in tissue and bone engineering, including guided bone regeneration (GBR). For effective and uninterrupted bone healing, a GBR membrane must maintain its functionality for an initial critical period of 4 weeks. A novel carp collagen sponge has already shown promise as a wound coating and vascular graft coating, making it a candidate for GBR applications as well. To enhance the mechanical properties and longevity of GBR membranes, we modified the basic carp collagen membrane with combinations of l-lactide, epsilon-caprolactone, d,l-lactide, and glycolide in various molar ratios. While traditional methods rely on histological evaluation to assess the degradation pattern and therefore suitability of GBR membranes ex vivo, this study employed micro-MRI as an innovative, noninvasive approach to monitor the in vivo degradation of carp collagen membrane and its polymer-modified variants. Our findings demonstrated that micro-MRI is a reliable and effective method for visualizing collagen membrane degradation in vivo, up to scaffold disintegration. Among the variants tested, collagen GBR membrane coated with d,l-lactide and glycolide in a 50:50 M ratio emerged as the most suitable for GBR purposes. However, since this study was conducted in the subcutaneous tissue of a rat model, further research is required to determine the behavior of carp collagen GBR membrane variants on bony surfaces.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biopolymers
ISSN
0006-3525
e-ISSN
1097-0282
Volume of the periodical
16
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
e70045
UT code for WoS article
001574387300001
EID of the result in the Scopus database
2-s2.0-105013541801