The influence of chemical structure of aliphatic polyesters on adhesion and growth of osteoblast-like MG63 cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F04%3A00104207" target="_blank" >RIV/67985823:_____/04:00104207 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The influence of chemical structure of aliphatic polyesters on adhesion and growth of osteoblast-like MG63 cells

Original language description

Degradable copolymers of glycolide and L-lactide (PGLA), glycolide and epsilon-caprolactone (PGCap) and terpolymer of glycolide, L-lactide and epsilon-caprolactone (PGLCap) were synthesized by ring opening polymerization and their interaction with osteoblast-like MG63 cells was tested in vitro. the cell behaviour on PGLA and PGLCap was very similar as on control tissue culture polystyrene (TCPS). On PGCap, however, the number of initially adhering cells was significantly lower (by 84% than on TCPS) andcell spreading area smaller (by 50%). On day 7 after seeding, these cells also reached the lowest populaton density. We hypothesize that the lower cell adhesion and growth of MG63 cells on PGCap was caused by the highest hydrophobicity of this material among all studied samples.

Czech name

Vliv chemické struktury alifatických polyesterů na adhesi a růst osteoblastických buněk MG 63

Czech description

Na degradovatelných kopolymerech glykolidu a L-lactidu (PGLA), glykolidu a epsilon-kaprolaktonu (PGCap) a terpolymeru glykolidu, L-laktidu a epsilon-kaprolaktonu (PGLCap) byla sledována adhese a růst osteogenních buněk MG 63 in vitro. Počet i adhesní plocha buněk na PGLA and PGLCap byl podobný jako na standardním polystyrénovém kultivačním substrátu, zatímco na PGCap byl tento počet i plocha významně nižší (o 84% a 50%). Rovněž plocha rozprostření buněk na PGCap kontaktu bu nižší and cell spreading areasmaller (by 50%). Navíc za 7 dní po nasazení dosáhly buňky na PGCap nejnižší populační density. Předpokládáme, že snížení adhese a růstu buněk na PGCap bylo způsobeno relativně vysokou hydrofobicitou tohoto materiálu

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EI - Biotechnology and bionics

OECD FORD branch

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Project

<a href="/en/project/OC%20527.130" target="_blank" >OC 527.130: In vitro biocompatibility and antimicrobial properties of biofunctional substrates coated with hard hydrocarbon polymer composite layers</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Engineering of Biomaterials

ISSN

1429-7248

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

37

Country of publishing house

PL - POLAND

Number of pages

4

Pages from-to

14-17

UT code for WoS article

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EID of the result in the Scopus database

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