CDC25A phosphatase controls meiosis I progression in mouse oocytes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F08%3A00307953" target="_blank" >RIV/67985904:_____/08:00307953 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

CDC25A phosphatase controls meiosis I progression in mouse oocytes

Original language description

This paper uses functional studies (RNAi, mRNA microinjection) to uncover a role of CDC25A in female meiosis. CDC25A cooperates together with CDC25B during resumption of meiosis, destruction of CDC25A in prometaphase I is crucial for MI-MII transition. CDC25A is exclusively localized to the nucleus prior to nuclear envelope breakdown (NEBD). In contrast, CDC25B localizes to cytoplasm in GV-intact oocytes and translocates to the nucleus shortly before NEBD. CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, MI spindle formation and the MI?MII transition. Thus, both CDC25A and CDC25B are critical for meiotic maturation of oocytes.

Czech name

CDC25A fosfatáza reguluje průchod meiózou I v myších oocytech

Czech description

Práce pomocí funkčních studií (RNAi, mRNA mikroinjekce) objasňuje roli CDC25A v samičí meióze. CDC25A se spolu s CDC25B podílí na znovuzahájení meiózy, destrukce CDC25A v prometafázi I je klíčová pro MI-MII přechod. CDC25A je před znovuzahájením meiózy čistě jaderný protein, avšak CDC25B je nejdříve lokalizována do cytoplasmy a těsně před rozpadem jaderné membrány se translokuje do jádra. CDC25A hraje klíčovou roli v znovuzahájení meiózy, v tvorbě MI spindlu a MI-MII přechodu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Developmental Biology

ISSN

0012-1606

e-ISSN

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Volume of the periodical

317

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

260-269

UT code for WoS article

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EID of the result in the Scopus database

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