Caspase-7 in molar tooth development

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F12%3A00386731" target="_blank" >RIV/67985904:_____/12:00386731 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/12:43871653

Result on the web

<a href="http://dx.doi.org/10.1016/j.archoralbio.2012.06.009" target="_blank" >http://dx.doi.org/10.1016/j.archoralbio.2012.06.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.archoralbio.2012.06.009" target="_blank" >10.1016/j.archoralbio.2012.06.009</a>

Result language

angličtina

Original language name

Caspase-7 in molar tooth development

Original language description

Objectives: The primary enamel knot (PEK) is a population of cells that shows spatio-temporal restricted apoptosis during tooth development. It has been shown that caspase-9 and Apaf-1 are essential for apoptosis in the PEK as well as the central caspase-3. Caspase-7, as another executioner member in the caspase machinery, is considered to have caspase-3 like properties. Design: The aim of this study was to detect caspase-7 activation during molar tooth development with a special focus on the cells of the PEK and to correlate the expression with the pattern of apoptosis and caspase-3 activation. Apoptosis in the PEK was investigated in caspase-7 deficient mice to examine the functional consequence of loss of this specific caspase. In addition, odontoblasts and ameloblasts, which are known to undergo cell death during their secretory and maturation stages, were investigated. Results: Cleaved caspase-7 was found in the apoptotic region of the PEK, however, caspase-7-deficient mice still

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Oral Biology

ISSN

0003-9969

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

1474-1481

UT code for WoS article

000312047200004

EID of the result in the Scopus database

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