Organization of the expanded cumulus-extracellular matrix in preovulatory follicles: arole for inter-alpha-trypsin inhibitor.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F15%3A00451700" target="_blank" >RIV/67985904:_____/15:00451700 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Organization of the expanded cumulus-extracellular matrix in preovulatory follicles: arole for inter-alpha-trypsin inhibitor.

Original language description

It has been shown that following endogenous gonadotropin surge, oocyte-cumulus complexes (OCC) synthesize hyaluronan (HA) in a process called cumulus expansion. During this process, HA associates with proteins and proteoglycans to form the expanded HA-rich oocyte-cumulus extracellular matrix (ECM), where the heavy chains of the serum derived inter-alpha-trypsin inhibitor family (IalphaI) bind covalently to HA. No study has been performed on the occurrence and regulation of this process during oocyte maturation in species other than mouse and pig, although, the heavy chains (of IalphaI)-HA complex was purified from human amniotic membrane. The present review pointing out that: 1/ formation of expanded HA-rich oocyte-cumulus ECM is dependent on the presence of IalphaI molecules, 2/ the heavy chains of IalphaI molecules identified in the serum are covalently linked to HA during cumulus expansion in mouse and pig, 3/ the family of IalphaI molecules can freely cross the blood-follicle barri

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/GA305%2F05%2F0960" target="_blank" >GA305/05/0960: Immunodetection of structural constituents in cumulus -extracellular matrix, that are crucial for female fertility.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endocrine Regulations

ISSN

1210-0668

e-ISSN

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Volume of the periodical

49

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

9

Pages from-to

37-45

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-84944177352