Unique hyaluronan structure of expanded oocyte-cumulus extracellular matrix in ovarian follicles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F24%3A00599147" target="_blank" >RIV/67985904:_____/24:00599147 - isvavai.cz</a>

Result on the web

<a href="https://sciendo.com/article/10.2478/enr-2024-0020" target="_blank" >https://sciendo.com/article/10.2478/enr-2024-0020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/enr-2024-0020" target="_blank" >10.2478/enr-2024-0020</a>

Result language

angličtina

Original language name

Unique hyaluronan structure of expanded oocyte-cumulus extracellular matrix in ovarian follicles

Original language description

In preovulatory follicles, after the endogenous gonadotropin surge, the oocyte-cumulus complexes (OCCs) produce hyaluronan (HA) in a process called 'cumulus expansion'. During this process, the heavy chains (HCs) of the serum-derived inter-alpha-trypsin inhibitor (IαI) family bind covalently to synthesized HA and form a unique structure of the expanded cumulus HA-rich extracellular matrix. Understanding the biochemical mechanism of the covalent linkage between HA and the HCs of the IαI family is one of the most significant discoveries in reproductive biology, since it explains basis of the cumulus expansion process running in parallel with the oocyte maturation, both essential for ovulation. Two recent studies have supported the above-mentioned findings: in the first, seven components of the extracellular matrix were detected by proteomic, evolutionary, and experimental analyses, and in the second, the essential role of serum in the process of cumulus expansion in vitro was confirmed. We have previously demonstrated the formation of unique structure of the covalent linkage of HA to HCs of IαI in the expanded gonadotropin-stimulated OCC, as well as interactions with several proteins produced by the cumulus cells: tumor necrosis factor-alpha-induced protein 6, pentraxin 3, and versican. Importantly, deletion of these genes in the mice produces female infertility due to defects in the oocyte-cumulus structure.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

10604 - Reproductive biology (medical aspects to be 3)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endocrine Regulations

ISSN

1210-0668

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

7

Pages from-to

174-180

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85201064398