Telemetry Physical Activity Monitoring in Minipig’s Model of Huntington’s Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F15%3A00452778" target="_blank" >RIV/67985904:_____/15:00452778 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/15:10315964 RIV/00064165:_____/15:10315964 RIV/67985904:_____/15:00476987

Result on the web

<a href="http://dx.doi.org/10.14735/amcsnn20152S39" target="_blank" >http://dx.doi.org/10.14735/amcsnn20152S39</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn20152S39" target="_blank" >10.14735/amcsnn20152S39</a>

Result language

angličtina

Original language name

Telemetry Physical Activity Monitoring in Minipig’s Model of Huntington’s Disease

Original language description

Animal models represent a key tool for Huntington’s disease (HD) research. During the last decade large animal models of HD have been established to improve knowledge of HD under large brain conditions. Transgenic minipig expressing N terminal part of human huntingtin with 124 CAG/ CAA repeats seems to be very promising HD model. Its previous characterization has shown various phenotypes affecting subcellular, cellular as well as organ systems level. The goal of this study was to detect and analyze a pathological pattern in physical activity of transgenic (TgHD) boars at the age of three years using telemetry approach. Into the study we have included five TgHD and five wild type (WT) animals for comparison. The physical activity was measured by the telemetric system rodentPACK2 whereas transmitter was placed into the collar. The analysis have shown significant decrease of total acceleration representing physical activity in TgHD boars between 4:40 and 5:30 a. m. (after night sleep  before morning feeding) in comparison with WT ones which could be explained with disturbed energy metabolism. Telemetry approach will play an important role in the study of physical activity and biopotentials essential for deeper characterization of large animal HD models in their preclinical and clinical phase.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a Slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

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Volume of the periodical

78

Issue of the periodical within the volume

Suppl 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

39-42

UT code for WoS article

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EID of the result in the Scopus database

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