Telemetry physical activity monitoring in minipig´s model of Huntington´s disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F15%3A00233612" target="_blank" >RIV/68407700:21230/15:00233612 - isvavai.cz</a>
Result on the web
<a href="http://www.csnn.eu" target="_blank" >http://www.csnn.eu</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14735/amcsnn20152s39" target="_blank" >10.14735/amcsnn20152s39</a>

Result language
angličtina
Original language name
Telemetry physical activity monitoring in minipig´s model of Huntington´s disease
Original language description
Animal models represent a key tool for Huntington´s disease (HD) research. During the last decade large animal models of Huntington´s disease have been established to improve knowledge of HD under large brain conditions. Transgenic minipig expressing N-terminal part of human huntingtin with 124CAG/CAA repeats seems to be very promising HD model. Its previous characterization has shown various phenotypes affecting subcellular, cellular as well as organ systems level. The goal of this study was to detectand analyze a pathological pattern in physical activity of transgenic (TgHD) boars at the age of three years using telemetry approach. Into the study we have included five TgHD and five wild type (WT) animals for comparison. The physical activity was measured by the telemetric system rodentPACK2 whereas transmitter was placed into the collar. The analysis have shown significant decrease of total acceleration representing physical activity in TgHD boars between 4:40 and 5:30 a.m. (after n
Czech name
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Czech description
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
The 3rd Conference on Animal Models for Neurodegenerative Diseases - proceedings book
ISBN
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ISSN
1210-7859
e-ISSN
—
Number of pages
4
Pages from-to
"2S39"-"2S42"
Publisher name
ČLS JEP
Place of publication
Praha
Event location
Liblice
Event date
Nov 8, 2015
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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