Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F16%3A00460675" target="_blank" >RIV/67985904:_____/16:00460675 - isvavai.cz</a>
Alternative codes found
RIV/68081715:_____/16:00460675 RIV/62157124:16170/16:43874060 RIV/00216224:14310/16:00095966
Result on the web
<a href="http://dx.doi.org/10.3390/ijms17060874" target="_blank" >http://dx.doi.org/10.3390/ijms17060874</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms17060874" target="_blank" >10.3390/ijms17060874</a>
Alternative languages
Result language
angličtina
Original language name
Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs
Original language description
The increasing amount of heavy metals used in manufacturing equivalently increases hazards of environmental pollution by industrial products such as cadmium oxide (CdO) nanoparticles. Here, we aimed to unravel the CdO nanoparticle destiny upon their entry into lungs by inhalations, with the main focus on the ultrastructural changes that the nanoparticles may cause to tissues of the primary and secondary target organs. We indeed found the CdO nanoparticles to be transported from the lungs into secondary target organs by blood. In lungs, inhaled CdO nanoparticles caused significant alterations in parenchyma tissue including hyperemia, enlarged pulmonary septa, congested capillaries, alveolar emphysema and small areas of atelectasis. Nanoparticles were observed in the cytoplasm of cells lining bronchioles, in the alveolar spaces as well as inside the membranous pneumocytes and in phagosomes of lung macrophages. Nanoparticles even penetrated through the membrane into some organelles including mitochondria and they also accumulated in the cytoplasmic vesicles. In livers, inhalation caused periportal inflammation and local hepatic necrosis. Only minor changes such as diffusely thickened filtration membrane with intramembranous electron dense deposits were observed in kidney. Taken together, inhaled CdO nanoparticles not only accumulated in lungs but they were also transported to other organs causing serious damage at tissue as well as cellular level.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
874-893
UT code for WoS article
000378799300088
EID of the result in the Scopus database
2-s2.0-84971668007