Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F17%3A00486688" target="_blank" >RIV/67985904:_____/17:00486688 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/17:00095658

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review

Original language description

AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer. These findings support the hypothesis that missing teeth may be a significant marker for predisposition for cancer.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

<a href="/en/project/NT11420" target="_blank" >NT11420: Molecular diagnostics of hypodontia and possibilities of tooth autotransplantation</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

3

Country of publishing house

SE - SWEDEN

Number of pages

7

Pages from-to

131-137

UT code for WoS article

000406690100001

EID of the result in the Scopus database

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