Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F18%3A00488579" target="_blank" >RIV/67985904:_____/18:00488579 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/18:00102008

Result on the web

<a href="http://dx.doi.org/10.1016/j.clnu.2017.06.004" target="_blank" >http://dx.doi.org/10.1016/j.clnu.2017.06.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clnu.2017.06.004" target="_blank" >10.1016/j.clnu.2017.06.004</a>

Result language

angličtina

Original language name

Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38

Original language description

Background & aims: We assessed orosensory detection of a long-chain fatty acid, linoleic acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster subjects with PROP detection and polymorphism in genes encoding bitter and lipid taste receptors, respectively, TAS2R38 and CD36, in normal weight and obese subjects. nDesign: The normal weight (n = 52, age = 35.3 +/- 4.10 years, BMI = 23.22 +/- 1.44 kg/m(2)) and obese (n = 52, age = 35.0 +/- 5.43 years, BMI = 34.29 +/- 531 kg/m(2)) participants were recruited to determine fat and bitter detection thresholds. The genomic DNA was used to determine single nucleotide polymorphism (SNP) of CD36 (rs1761667) and TAS2R38 (rs1726866 and rs10246939). nResults: The study included the participants who could detect LA, i.e., lipid-tasters. There was a positive correlation between BMI and detection thresholds for fat and bitter taste in normal weight and obese subjects. Obese participants showed a positive correlation between LA and PROP detection thresholds. PROP detection thresholds were higher for CD36 SNP (rs1761667) and TAS2R38 SNPs (rs1726866 and rs10246939) in obese participants compared to normal weight subjects. LA detection thresholds were not high for CD36 SNP (rs1761667) or TAS2R38 SNP (rs1726866 and rs10246939) in obese participants. nConclusions: Orosensory detection thresholds for fat and bitter taste are associated with BMI, and CD36 and TAS2R38 genotypes are not always associated with taste phenotypes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30105 - Physiology (including cytology)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Nutrition

ISSN

0261-5614

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

313-320

UT code for WoS article

000425564200041

EID of the result in the Scopus database

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