CD36 AA genotype is associated with decreased lipid taste perception in young obese, but not lean, children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F15%3A00445123" target="_blank" >RIV/67985904:_____/15:00445123 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/15:00082609

Result on the web

<a href="http://dx.doi.org/10.1038/ijo.2015.20" target="_blank" >http://dx.doi.org/10.1038/ijo.2015.20</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ijo.2015.20" target="_blank" >10.1038/ijo.2015.20</a>

Result language

angličtina

Original language name

CD36 AA genotype is associated with decreased lipid taste perception in young obese, but not lean, children

Original language description

Background/Objective: Obesity is an alarming threat for all age groups, including children. Fat overconsumption is one of the factors that directly influences this pathology. Recent studies have suggested that a common variant in the CD36 gene, that is, single-nucleotide polymorphism (SNP) rs1761667-A allele, that reduces CD36 expression, associates with high oral fat detection thresholds in some obese subjects. The objective was to assess fatty acid sensitivity in relation to CD36 SNP in young lean and obese children. Subjects/Methods: We studied lingual detection thresholds for emulsions, containing oleic acid, in Algerian children (n = 116, age = 80.5 years) who were divided into two groups: obese (n = 57; body mass index (BMI) z-score = 2.513 0.490) and lean children (n = 59; BMI z-score = -0.138 0.601) by alternative-forced choice method. To correlate the lipid taste perception thresholds with CD36 SNP, the children were genotyped for AG SNP rs1761667 in 5UTR region of CD36 by using PCR and restriction fragment length polymorphism. Results: We noticed significantly higher CD36 A-allele frequency (P = 0.036) in young obese children compared with leans. CD36 A-allele was associated with higher lipid taste perception thresholds than G-allele in obese children, but not in lean controls. Moreover, waist circumference was positively correlated with reduced fat taste sensitivity in these children. Conclusions: CD36 SNP A-allele, being present both in young lean and in obese children, is associated with high threshold for fatty acid taste sensitivity only in obese children.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Obesity

ISSN

0307-0565

e-ISSN

—

Volume of the periodical

39

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

920-924

UT code for WoS article

000356039500007

EID of the result in the Scopus database

2-s2.0-84930756224