Osteogenic and Angiogenic Profiles of Mandibular Bone-Forming Cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F19%3A00503664" target="_blank" >RIV/67985904:_____/19:00503664 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/19:43877577

Result on the web

<a href="https://doi.org/10.3389/fphys.2019.00124" target="_blank" >https://doi.org/10.3389/fphys.2019.00124</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphys.2019.00124" target="_blank" >10.3389/fphys.2019.00124</a>

Result language

angličtina

Original language name

Osteogenic and Angiogenic Profiles of Mandibular Bone-Forming Cells

Original language description

The mandible is a tooth-bearing structure involving one of the most prominent bones of the facial region. Mesenchymal cell condensation is the first morphological sign of osteogenesis, and several studies have focused on this stage also in the mandible. Little information is available about the early post-condensation period, during which avascular soft condensation turns into vascularized bone, and all three major bone cell types, osteoblasts, osteocytes, and osteoclasts, differentiate. In the mouse first lower molar region, the post-condensation period corresponds to the prenatal days 13-15. If during this critical period, when osteogenesis reaches the point of major bone cell differentiation, vascularization already has to play a critical role, one should be able to show molecular changes which support both types of cellular events. The aim of the present report was to follow in organ context the expression of major osteogenic and angiogenic markers and identify those that are up- or downregulated during this period. To this end, PCR Array was applied covering molecules involved in osteoblastic cell proliferation, commitment or differentiation, extracellular matrix (ECM) deposition, mineralisation, osteocyte maturation, angiogenesis, osteoclastic differentiation, and initial bone remodeling. From 161 analyzed osteogenic and angiogenic factors, the expression of 37 was altered when comparing the condensation stage with the bone stage. The results presented here provide a molecular survey of the early post-condensation stage of mandibular/alveolar bone development which has not yet been investigated in vivo.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10605 - Developmental biology

Project

<a href="/en/project/GA17-14886S" target="_blank" >GA17-14886S: Molecular and cellular dynamics of tooth-bone interface in model species with acrodont, pleurodont and thecodont dentition</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in physiology

ISSN

1664-042X

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

FEB 19

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

124

UT code for WoS article

000459160500001

EID of the result in the Scopus database

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