Revitalising the rudimentary replacement dentition in the mouse

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F19%3A00503702" target="_blank" >RIV/67985904:_____/19:00503702 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/19:00517901 RIV/00216224:14310/19:00109295 RIV/68378041:_____/19:00503702
Result on the web
<a href="https://dev.biologists.org/content/146/3/dev171363" target="_blank" >https://dev.biologists.org/content/146/3/dev171363</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/dev.171363" target="_blank" >10.1242/dev.171363</a>

Result language
angličtina
Original language name
Revitalising the rudimentary replacement dentition in the mouse
Original language description
Most mammals have two sets of teeth (diphyodont) - a deciduous dentition replaced by a permanent dentition, however, the mouse possesses only one tooth generation (monophyodont). In diphyodonts, the replacement tooth forms on the lingual side of the first tooth from the successional dental lamina. This lamina expresses the stem/progenitor marker Sox2 and has activated Wnt/beta-catenin signalling at its tip. Although the mouse does not replace its teeth, a transient rudimentary successional dental lamina (RSDL) still forms during development. The mouse RSDL houses Sox2-positive cells, but no Wnt/beta-catenin signalling. Here, we show that stabilising Wnt/beta-catenin signalling in the RSDL in the mouse leads to proliferation of the RSDL and formation of lingually positioned teeth. Although Sox2 has been shown to repress Wnt activity, overexpression of Wnts leads to a downregulation of Sox2, suggesting a negative-feedback loop in the tooth. In the mouse, the first tooth represses the formation of the replacement, and isolation of the RSDL is sufficient to induce formation of a new tooth germ. Our data highlight key mechanisms that may have influenced the evolution of replacement teeth.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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