Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00554914" target="_blank" >RIV/68378050:_____/21:00554914 - isvavai.cz</a>

Result on the web

<a href="https://journals.biologists.com/dev/article/148/14/dev199685/271019/Early-perturbation-of-Wnt-signaling-reveals" target="_blank" >https://journals.biologists.com/dev/article/148/14/dev199685/271019/Early-perturbation-of-Wnt-signaling-reveals</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1242/dev.199685" target="_blank" >10.1242/dev.199685</a>

Result language

angličtina

Original language name

Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development

Original language description

Tooth formation requires complex signaling interactions both within the oral epithelium and between the epithelium and the underlying mesenchyme. Previous studies of the Wnt/beta-catenin pathway have shown that tooth formation is partly inhibited in loss-of-function mutants, and gain-of-function mutants have perturbed tooth morphology. However, the stage at which Wnt signaling is first important in tooth formation remains unclear. Here, using an Fgf8-promoter-driven, and therefore early, deletion of beta-catenin in mouse molar epithelium, we found that loss of Wnt/beta-catenin signaling completely deletes the molar tooth, demonstrating that this pathway is central to the earliest stages of tooth formation. Early expression of a dominant-active p-catenin protein also perturbs tooth formation, producing a large domed evagination at early stages and supernumerary teeth later on. The early evaginations are associated with premature mesenchymal condensation marker, and are reduced by inhibition of condensation-associated collagen synthesis. We propose that invagination versus evagination morphogenesis is regulated by the relative timing of epithelial versus mesenchymal cell convergence regulated by canonical Wnt signaling. Together, these studies reveal new aspects of Wnt/beta-catenin signaling in tooth formation and in epithelial morphogenesis more broadly.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10605 - Developmental biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Development

ISSN

0950-1991

e-ISSN

1477-9129

Volume of the periodical

148

Issue of the periodical within the volume

14

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

dev199685

UT code for WoS article

000681398800018

EID of the result in the Scopus database

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