WNT/β-Catenin Signaling in Vertebrate Eye Development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00472721" target="_blank" >RIV/68378050:_____/16:00472721 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fcell.2016.00138" target="_blank" >http://dx.doi.org/10.3389/fcell.2016.00138</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2016.00138" target="_blank" >10.3389/fcell.2016.00138</a>
Alternative languages
Result language
angličtina
Original language name
WNT/β-Catenin Signaling in Vertebrate Eye Development
Original language description
The vertebrate eye is a highly specialized sensory organ, which is derived from the anterior neural plate, head surface ectoderm, and neural crest-derived mesenchyme. The single central eye field, generated from the anterior neural plate, divides to give rise to the optic vesicle, which evaginates toward the head surface ectoderm. Subsequently, the surface ectoderm, in conjunction with the optic vesicle invaginates to form the lens vesicle and double-layered optic cup, respectively. This complex process is controlled by transcription factors and several intracellular and extracellular signaling pathways including WNT/β-catenin signaling. This signaling pathway plays an essential role in multiple developmental processes and has a profound effect on cell proliferation and cell fate determination. During eye development, the activity of WNT/β-catenin signaling is tightly controlled. Faulty regulation of WNT/β-catenin signaling results in multiple ocular malformations due to defects in the process of cell fate determination and differentiation. This mini-review summarizes recent findings on the role of WNT/β-catenin signaling in eye development. Whilst this mini-review focuses on loss-of-function and gain-of-function mutants of WNT/β-catenin signaling components, it also highlights some important aspects of β-catenin-independent WNT signaling in the eye development at later stages.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LQ1604" target="_blank" >LQ1604: BIOCEV: from Fundamental to Applied Research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in cell and developmental biology
ISSN
2296-634X
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
November
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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