Tcf7l1 protects the anterior neural fold from adopting the neural crest fate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00472090" target="_blank" >RIV/68378050:_____/16:00472090 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1242/dev.132357" target="_blank" >http://dx.doi.org/10.1242/dev.132357</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/dev.132357" target="_blank" >10.1242/dev.132357</a>
Alternative languages
Result language
angličtina
Original language name
Tcf7l1 protects the anterior neural fold from adopting the neural crest fate
Original language description
The neural crest (NC) is crucial for the evolutionary diversification of vertebrates. NC cells are induced at the neural plate border by the coordinated action of several signaling pathways, including Wnt/beta-catenin. NC cells are normally generated in the posterior neural plate border, whereas the anterior neural fold is devoid of NC cells. Using the mouse model, we show here that active repression of Wnt/beta-catenin signaling is required for maintenance of neuroepithelial identity in the anterior neural fold and for inhibition of NC induction. Conditional inactivation of Tcf7l1, a transcriptional repressor of Wnt target genes, leads to aberrant activation of Wnt/beta-catenin signaling in the anterior neuroectoderm and its conversion into NC. This reduces the developing prosencephalon without affecting the anterior-posterior neural character. Thus, Tcf7l1 defines the border between the NC and the prospective forebrain via restriction of the Wnt/beta-catenin signaling gradient.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Development
ISSN
0950-1991
e-ISSN
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Volume of the periodical
143
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
2206-2216
UT code for WoS article
000390417400016
EID of the result in the Scopus database
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