A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00094481" target="_blank" >RIV/68378050:_____/07:00094481 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus

Original language description

Neurogenesis in developing neocortex is strictly regulated. We report gradual retreat of canonical Wnt signaling in the cortex from lateral-to-medial and anterior-to-posterior as a neurogenesis prerequisite. Ectopic expression of a beta-catenin/LEF1 fusion protein maintains active canonical Wnt signaling in developing cortex and delays expression onset of neurogenic factors Pax6, Ngn2, Tbr2, and subsequent neurogenesis. Contrary to this, conditional ablation of beta-catenin accelerates expression of thesame neurogenic genes. We also show sustained canonical Wnt activity in the lateral cortex to give rise to cells with hippocampal characteristics in the cortical plate at the expense of cortical fate and to cells with dentate gyrus characteristics in hippocampus. The canonical Wnt signaling dose seems to determine cellular fate in developing cortex and hippocampus and recession of Wnt signaling seems to act as a morphogenetic gradient regulating neurogenesis in the cortex.

Czech name

Dynamický gradient přenosu signálu Wnt reguluje iniciaci neurogeneze v savčím kortexu a buněčnou specifikaci v hipokampu

Czech description

Neurogeneze je přísně regulovaný proces buněčného dělení a diferenciace. Zde jsme prokázali, že postupný úbytek kanonické wnt signalizace v mozkové kůře je předpokladem pro neurogenezi. Navíc, naše výsledky ukazují, že trvalé zapnutí canonical wnt aktivity v kůře dává vzniknout buňkám s hippocampálními vlastnostmi. To naznačuje, že dávka wnt signálu určuje buněčných osud v vyvíjející se kůře a hippokampu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/1M0520" target="_blank" >1M0520: Center for Applied Genomics</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Developmental Biology

ISSN

0012-1606

e-ISSN

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Volume of the periodical

311

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

223-237

UT code for WoS article

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EID of the result in the Scopus database

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