Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F05%3A00028463" target="_blank" >RIV/68378050:_____/05:00028463 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
Original language description
Wnt signaling is involved in numerous processes during vertebrate CNS development. In this study, we used conditional Cre/loxP system in mouse to ablate or activate beta-catenin in the telencephalon in two time windows: before and after the onset of neurogenesis. We show that beta-catenin mediated Wnt signals are required to maintain the molecular identity of the pallium. Inactivation of beta-catenin in the telencephalon before neurogenesis results in downregulated expression of dorsal markers Emx1, Emx2 and Ngn2, and in ectopic up-regulation of ventral markers Gsh2, Mash1 and Dlx2 in the pallium. Thus, our data suggest that canonical Wnt signals are involved in maintaining the identity of the pallium by controlling expression of dorsal markers and bysuppressing ventral programs from being activated in pallial progenitor cells.
Czech name
Efekt dráhy Wnt na dorso-ventrální specifikaci telencephalonu
Czech description
Dráha Wnt se účastní řady procesů během vývoje centrální nervové soustavy (CNS). Použili jsme kondicionální systém CRE/loxP abychom inaktivovali gen pro beta-katenin před a po začátku neurogeneze. Ukázalo se, že dráha Wnt udržuje identitu buněk v CNS kontrolou exprese dorsálních markerů a supresí ventrálních markerů.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA204%2F04%2F1358" target="_blank" >GA204/04/1358: The role of wnt signalling in eye development and lens cell differentiation</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Developmental Biology
ISSN
0012-1606
e-ISSN
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Volume of the periodical
279
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
155-168
UT code for WoS article
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EID of the result in the Scopus database
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