Cutibacterium avidum is phylogenetically diverse with a subpopulation being adapted to the infant gut
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F19%3A00509389" target="_blank" >RIV/67985904:_____/19:00509389 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41210/19:80343
Result on the web
<a href="https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=2250998247" target="_blank" >https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=2250998247</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.syapm.2019.05.001" target="_blank" >10.1016/j.syapm.2019.05.001</a>
Alternative languages
Result language
angličtina
Original language name
Cutibacterium avidum is phylogenetically diverse with a subpopulation being adapted to the infant gut
Original language description
The infant gut harbors a diverse microbial community consisting of several taxa whose persistence depends on adaptation to the ecosystem. In healthy breast-fed infants, the gut microbiota is dominated by Bifido bacterium spp.. Cutibacterium avidum is among the initial colonizers, however, the phylogenetic relationship of infant fecal isolates to isolates from other body sites, and C. avidum carbon utilization related to the infant gut ecosystem have been little investigated. nIn this study, we investigated the phylogenetic and phenotypic diversity of 28 C. avidum strains, including 16 strains isolated from feces of healthy infants. We investigated the in vitro capacity of C. avidum infant isolates to degrade and consume carbon sources present in the infant gut, and metabolic interactions of C. avidum with infant associated Bifidobacterium longum subsp. infantis and Bifidobacterium bifidum. nIsolates of C. avidum showed genetic heterogeneity. C. avidum consumed D- and L-lactate, glycerol, glucose, galactose, N-acetyl-n-glucosamine and maltodextrins. Alpha-galactosidase- and beta-glucuronidase activity were a trait of a group of non-hemolytic strains, which were mostly isolated from infant feces. Beta-glucuronidase activity correlated with the ability to ferment glucuronic acid. Co-cultivation with B. infantis and B. bifidum enhanced C. avidum growth and production of propionate, confirming metabolic cross-feeding. nThis study highlights the phylogenetic and functional diversity of C. avidum, their role as secondary glycan degraders and propionate producers, and suggests adaptation of a subpopulation to the infant gut.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Systematic and Applied Microbiology
ISSN
0723-2020
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
506-516
UT code for WoS article
000474343600009
EID of the result in the Scopus database
2-s2.0-85065866431